Common medicines may cut cancer drug potency: study

(Reuters) - Many patients taking a widely prescribed class of oral cancer drugs are also using a variety of medications that could reduce the effectiveness of the cancer treatment or increase its toxic side effects, according to research by Medco Health Solutions Inc.

For example, 43 percent of patients taking the highly effective leukemia drug Gleevec were also on another medicine that could diminish its efficacy, while 68 percent were taking something that could potentially raise the toxicity level, the study found.

Not surprisingly, the study found that the vast majority of the cancer drugs were prescribed by an oncologist, while the other medicines were typically prescribed by a primary care physician.

"More communication needs to take place across all doctors that are prescribing for the patient," said Medco's Steve Bowlin, who is presenting the study findings on Friday at the American Society for Clinical Pharmacology and Therapeutics meeting in Washington.

The Medco drug interaction study looked at pharmacy claims of about 11,600 patients who had been prescribed any of nine oral drugs known as kinase inhibitors, used to treat a variety of cancers. They include Gleevec and Tasigna from Novartis; Pfizer Inc's Sutent; Nexavar from Onyx Pharmaceuticals Inc and Bayer AG; Tarceva, sold by Roche Holding and Japan's Astellas Pharma Inc; Sprycel from Bristol-Myers Squibb Co; and GlaxoSmithKline Plc's Tykerb.

The medications that could potentially cause such adverse "drug-drug interactions" (DDI) include commonly used heartburn drugs known as proton pump inhibitors (PPIs), such as Nexium and Prevacid; steroids; a class of blood pressure and heart medications known as calcium channel blockers; and some antibiotics and antifungal treatments.

At the high end of the range, 74 percent of patients who were taking Glaxo's kidney cancer drug Votrient were also taking a drug that could increase toxicity, researchers said.

Fifty-seven percent of Tarceva patients were also taking a drug that could weaken effectiveness, more than for any of the other cancer treatments.

Sutent had the lowest incidence of potentially troubling drug interactions, with 23 percent of patients taking a medicine that could decrease its effectiveness and 24 percent on a drug that could increase Sutent's toxicity.

"The fact that one-quarter to 75 percent of patients on these oral drugs may not be getting the full benefit of their treatment or may in fact be putting their health at further risk because of another medication they are taking is concerning," Dr. Milayna Subar of Medco's Oncology Therapeutic Resource Center said in a statement.

The PPI drugs for heartburn and acid reflux were the most likely to alter the effectiveness and toxicity of Gleevec, researchers said. For the lung cancer drug Tarceva, steroids and PPIs were most likely to decrease efficacy, while certain antibiotics were most likely to increase toxicity.

Even though the Tarceva label cautions against using the antibiotic ciprofloxacin when taking that cancer drug, the analysis found that the two were co-prescribed for a significant number of patients.

"There are other therapeutic alternatives that could be prescribed that would not have the same potential for interaction," said study co-author Eric Stanek, who called for increased surveillance of patient prescribing.

The analysis also found that the overlap for patients taking one of the oral cancer drugs and a medicine that could cause problems was rarely for just a day or two.

"In many instances, 30 or 40 percent of the time people were on a cancer drug they were also on a DDI drug," Bowlin said. "On average, it was substantial amount of time."

Medco, a pharmacy benefit manager that is in the process of being acquired by rival Express Scripts Inc, offers a Drug Utilization Review program under which its oncology pharmacists can alert doctors about potentially troubling medication interactions.

(Reporting By Bill Berkrot; Editing by Gerald E. McCormick)

Source: http://news.yahoo.com/common-medicines-may-cut-cancer-drug-potency-study-040737250.html

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ARTICLES MANIAC ? How To Tackle Easy Home Improvement Jobs

If you have a house, then chances are you have looked around and thought how nice it would be to make some home improvements. But, rest assured that better times really are ahead, and then you can look in earnest and do something. There is always something that can be done, and we are about to reveal what that is. Perhaps stop being so grandiose, and there are many possibilities on the horizon with a change in thought. At the heart of the matter is becoming better informed so you realize just what is possible.

Clearly, if you cannot afford the truly expensive projects, then it is best to forgo them at this time; but that leaves many more on the table. So let?s consider what is possible that will make your home stronger. Working to give your home what it needs will allow it to give you a better living experience.

Very many people turn to the common security cameras when they want to put improvements in place. The first thing you have to do is assess your property and determine what you need. Very many companies are designing wireless video cameras which helps with remote locations. What adds another dimension to this are all the clever designs that intend to camouflage your cameras. No need to worry if you cannot afford a lot because these devices are priced all over the place.

You may have never thought about putting a nice fan in the attic area, and if not then do consider this home improvement idea. This is something that really should not set you back a lot, and it is even better if you can do that job your self. Attic fans will give your home some more efficiency and that will add some cost savings for energy. This is a home improvement job that most people will not want to do for one reason or another, so simply find a reputable person for the task. All around the fan will have to be sealed with caulk or RTV very well because you do not want a leak.

If you have been in the same home for ten years or more, or even five years, then you have accumulated a lot and can get organized. One simple and very cost effective solution is to look at closet organizers or organizing systems. One of the most popular places are the larger retail outlet monopolistic type of stores that destroy small businesses in cities. Plastic is usually used and for obvious reasons, and in the old days they used wood. The most typical places to stack these boxes are in the usual places we all throw things to just get them out of the way. There are many different kinds of home improvement projects you can do that will not break your bank. There is a lot you can do that is preventive and serves a valuable purpose. You would be surprised at the number of smaller projects that are done relatively fast. These are what will make a big difference over the years, so it is all in your best interest to do them. We are talking about ROI, or return on your investment, and besides we have to be concerned about energy conservation.

Find out veterinarian nj resources which comprise articles, cases, videos and much more helping you to study essence of finding good veterinarian. Study lawyers mesothelioma, acquire the knowledge needed to select the best and most experienced lawyer.

Source: http://articles-maniac.tk/how-to-tackle-easy-home-improvement-jobs/home-family/

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[unable to retrieve full-text content]air jordan 3 black Self Improvement Creativity Art. The BBC/Horizon agenda has recently escape a documentary phoned?Do you discern what I perceive which was about the illusion of colour. Scientists ran a diversity of ...

Source: http://dwsxgfs22.lateststyle.org/2012/03/13/air-jordan-3-black-self-improvement-creativity-art/

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Ideas on Many Types of Exotic Pets | Articles Effect

Inasmuch as as achievable stay away from commercially ready rabbit foods. These foods are generally packed with starchy foods and excess fat. They are built to the bunnies taste, in order that the rabbit loves eating it. What is going to result is any rabbit in which grows fat very fast. Several would feel that this is very excellent, but just the contrary. Unwanted fat will be accumulating within your chubby seeking rabbit. Several nutrients within natural foods may not be within commercial foods. No doubt, the rabbit can look cute and also chubby for quite a while, but ultimately it will commence to suffer. Any plump excess fat rabbit isn?t a healthy rabbit. Healthy bunnies are those who have a strong buff tone together with minimal excess fat. The proper diet regime with enough workout ensures this kind of.

When choosing your pet parrot, you should thus, consider certain aspects. The first one would be keeping the members and the atmosphere of your house in mind. If you have children at home, buying big parrots such as the African grays, the macaws and the Amazons would not be advisable since these birds may prove to be harmful to the little ones. You must also remember that you must not buy a parrot if you have other pets at home that may harm your parrot. The second aspect would be considering the surroundings of your house, especially your neighbors. Birds which make a lot of noise and which are too loud, such as the cockatoos, the Amazons, the macaws and the African grays may disturb your neighbors. Thus, in this aspect, birds with little ability to scream such as the lovebirds, the budgies and the parrotlets must be considered. However, these large and loud birds may prove to be much more intelligent and entertaining than the others. They may also have better abilities to mimic, learn what they are taught and replicate it in their speech and behavior.

One of the most smashing sources of anxiety is being lonely. The modern world provides cause us all to sense alienated. Sometimes, specifically in the big towns, we will no longer feel local community. Spending time with our own pet let?s us all experience a thing that we may not necessarily know that we have been missing: company. Animals are fantastic company. We could talk with these freely. Even though, unless the pet is a bird, it won?t discuss back. Once we feel unhappy and frightened, a pet will make our difficulties disappear.

Recent times, captive mating projects are suffering from several intriguing NLP color kinds which almost all share the identical guidelines. Getting ball python from your reputable cat breeder will also make certain you will get the exact help and assistance you need to help make your ball python can feel comfortable and also secure adequate to eat when you bring it any t residence.

Food is the other main consideration. Lizards have different digestive systems to mammals. Feeding them snacks like chocolate and candy is a bad idea and could potentially kill you pet. Depending on which species you choose, you are more likely to be feeding it vegetables, fruit, insects and worms. You need to carefully research the diet of your chosen lizard. This is one of the most important ways to keep it in good health fr the long term.

Amy Whitehouse is a health news writer and affiliate of many kinds of healthy products and weight loss programs.

Source: http://www.articleseffect.com/ideas-on-many-types-of-exotic-pets.html

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Amazon May Have Sold Two Million 'Kindle Singles', But Why's That Impressive? [Amazon]

This morning, the internet is awash with people slapping Amazon on the back, congratulating them for selling two million Kindle Singles—e-books that are shorter than full-length books but longer than most magazine articles. But is that really a big deal? More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/bGekwM8heHI/amazon-may-have-sold-two-million-kindle-singles-but-whys-that-impressive

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War film maker Pierre Schoendoerffer dies at 83

PARIS (AP) ? Pierre Schoendoerffer, an Oscar-winning French filmmaker who was held prisoner in Indochina and chronicled the pain of war on screen and on the page, has died. He was 83.

The French military health service confirmed that he died Wednesday. France's Le Figaro newspaper said Schoendoerffer died in a hospital outside Paris after an operation.

"France will miss him," President Nicolas Sarkozy said in a statement that praised the "legendary filmmaker and novelist" for risking his life for France and "helping us better understand our collective history."

Born in central Franceo on May 5, 1928, Schoendoerffer served as a cameraman in the French army in the 1950s and volunteered to be parachuted into the besieged fortress of Dien Bien Phu, where the decisive battle of the French war in Indochina was fought.

When the stronghold fell to the Vietnamese guerrilla army in May 1954, Schoendoerffer was captured and spent four months in a POW camp before being repatriated.

After the war, Schoendoerffer became a war correspondent in Algeria, and also worked in Malaysia, Morocco, Yemen and Laos.

He first gained fame as a film director for the gritty realism of his 1965 film "The 317th Platoon," which traced of a doomed group of French and Laotian soldiers retreating through the jungles ahead of the final rebel offensive in 1954. Critics have described the black-and-white film as a masterpiece among war movies in general, and among the best Vietnam War films ever made.

Schoendoerffer also made his mark as a screenwriter for his 1975 film "Drummer Crab" ? based on a book he wrote by the same name ? and the 1982 film "A Captain's Honor."

In 1991, he returned to Vietnam to film "Dien Bien Phu," a big-budget docudrama about the 55-day battle that ended France's colonial rule in Indochina and marked the start of the U.S. involvement there.

Schoendoerffer won an Academy Award in 1968 for his documentary "The Anderson Platoon," filmed in Vietnam.

In honoring Schoendoerffer, Sarkozy's office referred to this year's Oscar success of the French-directed film "The Artist."

"At a moment when our cinema is triumphing in the world, the chief of state salutes, in Pierre Schoendoerffer, one of the very rare French directors who, thanks to the universality of his message, won an Oscar."

___

Slobodan Lekic in Brussels contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-03-14-EU-France-Obit-Schoendoerffer/id-ae41ef8e9d24400298488289c04da8b6

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Slug ecology and management in no-till field crops

Public release date: 14-Mar-2012
[ | E-mail | Share ]

Contact: Richard Levine
rlevine@entsoc.org
301-731-4535
Entomological Society of America

Integrated pest management options and suggestions for growers offered in this free, open-access article

As acreage of row crops managed with conservation tillage increases, more growers are encountering slugs, elevating their importance as crop pests. Slugs can eat virtually all crops, and they are challenging to control because of the limited number of management tactics that are available.

In "Slug (Mollusca: Agriolimacidae, Arionidae) Ecology and Management in No-Till Field Crops, With an Emphasis on the mid-Atlantic Region," a free, open-access article appearing in the Journal of Integrated Pest Management, the authors discuss the species of slugs that are commonly found in mid-Atlantic field crop production and discuss their natural history, ecology, and some of the factors limiting their populations.

The authors also suggest possible cultural, biological, and chemical management options, particularly for corn production, and they suggest elements of a potential integrated management program for slugs.

Over 15 slug species occur in the mid-Atlantic United States, but only four appear to be common in field crops.

The authors provide photos and descriptions of all four to make identification and management easier for growers, and they describe their life cycles as well.

Host plant species, scouting methods, environmental influences, natural enemies, biocontrol options, and management options are also discussed.

###

The full article is availabe for free at http://bit.ly/zZ3gYs.

The Journal of Integrated Pest Management (http://entsoc.org/Pubs/Periodicals/jipm) is an open-access, peer-reviewed, extension journal covering the field of integrated pest management. The intended readership for the journal is any professional who is engaged in any aspect of integrated pest management, including, but not limited to, crop producers, individuals working in crop protection, retailers, manufacturers and suppliers of pest management products, educators, and pest control operators.

JIPM is published by the Entomological Society of America (ESA), the largest organization in the world serving the professional and scientific needs of entomologists and people in related disciplines. Founded in 1889, ESA today has more than 6,000 members affiliated with educational institutions, health agencies, private industry, and government. Members are students, researchers, teachers, extension service personnel, administrators, marketing representatives, research technicians, consultants, and hobbyists. For more information, please visit http://www.entsoc.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 14-Mar-2012
[ | E-mail | Share ]

Contact: Richard Levine
rlevine@entsoc.org
301-731-4535
Entomological Society of America

Integrated pest management options and suggestions for growers offered in this free, open-access article

As acreage of row crops managed with conservation tillage increases, more growers are encountering slugs, elevating their importance as crop pests. Slugs can eat virtually all crops, and they are challenging to control because of the limited number of management tactics that are available.

In "Slug (Mollusca: Agriolimacidae, Arionidae) Ecology and Management in No-Till Field Crops, With an Emphasis on the mid-Atlantic Region," a free, open-access article appearing in the Journal of Integrated Pest Management, the authors discuss the species of slugs that are commonly found in mid-Atlantic field crop production and discuss their natural history, ecology, and some of the factors limiting their populations.

The authors also suggest possible cultural, biological, and chemical management options, particularly for corn production, and they suggest elements of a potential integrated management program for slugs.

Over 15 slug species occur in the mid-Atlantic United States, but only four appear to be common in field crops.

The authors provide photos and descriptions of all four to make identification and management easier for growers, and they describe their life cycles as well.

Host plant species, scouting methods, environmental influences, natural enemies, biocontrol options, and management options are also discussed.

###

The full article is availabe for free at http://bit.ly/zZ3gYs.

The Journal of Integrated Pest Management (http://entsoc.org/Pubs/Periodicals/jipm) is an open-access, peer-reviewed, extension journal covering the field of integrated pest management. The intended readership for the journal is any professional who is engaged in any aspect of integrated pest management, including, but not limited to, crop producers, individuals working in crop protection, retailers, manufacturers and suppliers of pest management products, educators, and pest control operators.

JIPM is published by the Entomological Society of America (ESA), the largest organization in the world serving the professional and scientific needs of entomologists and people in related disciplines. Founded in 1889, ESA today has more than 6,000 members affiliated with educational institutions, health agencies, private industry, and government. Members are students, researchers, teachers, extension service personnel, administrators, marketing representatives, research technicians, consultants, and hobbyists. For more information, please visit http://www.entsoc.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-03/esoa-sea031412.php

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