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Geeky Gadgets
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Scorecard
Ben Hilfenhaus took five wickets including the last scalp of R Ashwin (62) as India were bowled out for 400 runs in their second innings.
Australia were just one wicket away from an innings victory as Nathan Lyon trapped Ishant Sharma plumb in front of the wicket soon after R Ashwin's fifty.
Staring at an innings defeat, India were 351/8 in their second innings at tea.
India lost their eighth wicket when Peter Siddle had Zaheer Khan caught by Shaun Marsh, who took a fine tumbling catch over his head in the covers. Zaheer hit 35 from 26 balls with the help of a six and 5 fours.
India lost Sachin Tendulkar, VVS Laxman, captain MS Dhoni and Virat Kohli in quick succession.
James Pattinson got his first wicket when he trapped Kohli plumb in front of the wicket with a full straight delivery that Kohli tried to get across and flick but missed. The ball stayed low as well and hit him right in front.
Ben Hilfenhaus took his fourth wicket by dismissing Dhoni taking an easy return catch. Dhoni looked to drive the full delivery but hit it back without control. It lobbed up to Hilfenhaus who took it easily. It initially seemed as if it was a bump ball as Hilfenhaus did not celebrate, but the slip cordon came haring down in celebration. The on-field umpires referred to the third umpire and the replays showed that the ball came directly off the face of the bat towards the bowler.
Hilfenhaus dismissed Laxman with the second new ball that was pitched full just outside off and moved away just a touch. Laxman was squared up in defense and the ball went past the bat's edge to clip the off-stump leaving Laxman stunned.
Laxman hit 7 fours in his 66-run knock.
Tendulkar missed his 100th ton yet again as Australian captain Michael Clarke had him caught by Michael Hussey at first slip for 80.
Clarke tossed up a delivery outside off, Tendulkar came forward to defend but the ball spun away and took the outside edge, it went to Brad Haddin who was slow in getting up, but such was the luck for Tendulkar that the ball went off Haddin's gloves towards Hussey at first slip.
The moment Tendulkar's wicket fell there was stunned silence at the SCG and one could hear only Haddin and Hussey screaming in delight. Then the crowd gave the master a standing ovation as he departed for a wonderful 80.
Tendulkar hit 9 fours and added 104 runs with VVS Laxman for the fourth wicket.
India lost Gautam Gambhir in the first session.
Laxman scored a 92-ball 50 soon after lunch, which included six fours, to take India past the 250-run mark.
India, resumed at 114/2 on Friday, lost overnight batsman Gambhir (83) but scored 129 runs off 27 overs during the two-hour session.
Tendulkar hit a fighting half-century to lead India's battle alongwith VVS Laxman against the Aussies. Tendulkar's fifty came in 89 balls with the help of seven boundaries.
Earlier in the day, seamer Peter Siddle, who replaced Ben Hilfenhaus, gave Australia a crucial breakthrough as he got rid of Gambhir.
Gambhir, who scored 83 of 142 balls with the help of 11 fours, tried to play the shot on the on-side but it took the leading edge which was well caught by David Warner at point.
Gambhir and Tendulkar added 68 runs for the third wicket.
The conditions were little overcast on Day 4 due to some showers on Thursday evening but the weather is perfectly fine for the game of cricket at the SCG.
India, who have never won a Test series in Australia, reached third day stumps at 114 for two, 354 behind, with Gautam Gambhir on 68 and Sachin Tendulkar eight.
Earlier on the third day of the Test, Indian opener Virender Sehwag (4) and an uncertain Rahul Dravid (29) were cooling their heels in the pavilion, which raises the possibility of an innings defeat in the match.
Michael Hussey remained unbeaten on 150 but the glory of the day belonged to Australian skipper Michael Clarke who was left unconquered on 329, the highest score ever made at the SCG, which is hosting its 100th Test.
Triple centurion Michael Clarke put team interests ahead of personal glory as Australia moved towards a crushing win over India in the second Test.
Captain Clarke, unbeaten on 329, declared Australia's first innings closed at 659 for four to press for victory - despite various individual milestones beckoning.
After building a massive 468-run lead, Clarke called a halt to the onslaught to give his attack seven and a half sessions to bowl India out.
He was rewarded with the key wickets of Virender Sehwag and Rahul Dravid as the tourists dug in to save going 2-0 down in the four-Test series.
India had an early stumble when big-hitter Sehwag was brilliantly plucked from the air by the athletic David Warner at point off Ben Hilfenhaus for four.
Dravid's reputation as "The Wall" took another hit when he was out bowled for the third time in the series, this time by Hilfenhaus for 29.
Gambhir was lucky enough to survive after he was dropped by wicketkeeper Brad Haddin on 66 off James Pattinson in the penultimate over of the day.
Clarke's score is the fourth highest score by an Australian in Test cricket, behind Matthew Hayden (380), Sir Donald Bradman (334) and Mark Taylor (334).
This was the 25th instance of a triple century in Test cricket. Only Bradman, Brian Lara, Virender Sehwag and Chris Gayle are the four batsmen who have hit triple century twice in Tests.
Source: http://timesofindia.feedsportal.com/fy/8at2Etd0VIQkf1Yr/story01.htm
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Syrian TV via Reuters
Syrian TV pictures show the aftermath of a bomb explosion in Damascus on Friday.
By msnbc.com news services
Updated at 6:59 a.m. ET
DAMASCUS -- An explosion ripped through a police bus in the center of Syria's capital Friday, killing at least 10 people in an attack authorities blamed on a suicide bomber, a Syrian official and state-run TV said.
However, Reuters reported that local news station Addounia put the death toll at 25.?Addounia said?46 others were wounded.?
Although the nearly 10-month-old uprising in Syria has convulsed many parts of the country, Damascus has been relatively quiet under the tight control of ruthless security agencies loyal to President Bashar Assad.
The government has long contended that the turmoil in Syria this year is not an uprising but the work of terrorists and foreign-backed armed gangs.
The opposition?has questioned those allegations. It has hinted that the regime itself could have been behind?a Dec. 23?bombing?targeting the?country's intelligence agencies. At least 44 people were killed and?166 others were?injured in that attack.
Published at 5:47 a.m. ET: A suicide bomber killed and wounded dozens of people in central Damascus, Syrian?state TV said Friday.
Footage broadcast by Syria Television showed the shattered windows of what appeared to be a police bus.
Syrian TV via Reuters
Syrian state television said the attack at an intersection in the center of the capital killed mostly civilians.
State TV?said the?explosion went off at an intersection in the neighborhood of Midan, while scores of people were in the area. It said most of the casualties were civilians.
Syria has banned most foreign journalists from the country and prevented independent reporting.
The explosion comes two weeks after two blasts in Damascus targeting security buildings killed 44 people.
A Syrian official, speaking on condition of anonymity because he was not allowed to talk publicly to the media, said the target of the attack appeared to be a bus carrying police officer.
"This is a criminal terrorist act," a man shouted in footage aired on Syria TV.
For months, President Bashar Assad has used tanks and troops to try to crush street protests inspired by other Arab uprisings.
According to the U.N.,?more than 5,000 people have been killed during the uprising against the Assad regime.
More from msnbc.com and NBC News:
The Associated Press and Reuters contributed to this report.
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LOS ANGELES?? A California lawmaker who is a vocal advocate for gun rights was briefly detained at an airport on Wednesday after bringing a loaded gun to a security checkpoint, authorities said.
Don't miss these Travel stories
To go or not to go? Places that make headlines for the wrong reasons?can also become travel bargains.
California state Assemblyman Tim Donnelly, a Republican, was cited and released, Los Angeles Airport Police said in a statement. Donnelly said he forgot he had packed the gun in a carry-on bag.
He was stopped at a U.S. Transportation Security Administration X-ray screening station when a .45-caliber Colt handgun was discovered, said Nico Melendez, a spokesman for the agency.
Donnelly was on his way to board a Southwest Airlines flight at Ontario International Airport, about 40 west of Los Angeles. The flight was destined for the state capital Sacramento.
His gun had four rounds inside and a spare magazine had an additional five rounds, Melendez said.
"When I arrived at the security check point, an X-ray machine revealed that I had forgotten to remove a gun from my carry-on luggage," Donnelly said in a written statement.
"At that time, I was questioned by airport police, cited for possession of an unloaded firearm. I was released as soon as it was determined that I was not a threat. I boarded the next flight without incident," he said.
Donnelly was mistakenly cited for possession of an unloaded firearm, but his citation would be changed to possession of a loaded gun because the weapon had rounds inside, airport police said in a statement.
The gun was handed over to the Ontario Police Department.
The citation for possession of a gun is a misdemeanor, and Donnelly faces a maximum of one year in jail and a $1,000 fine, Airport Police spokeswoman Sergeant Belinda Nettles said.
TSA agents found more than 1,200 handguns in carry-on bags at U.S. airports in 2011, Melendez said.
Donnelly has been a vocal advocate for gun rights, and he sharply criticized California Governor Jerry Brown last year when the Democrat signed into law a ban on openly carrying handguns in the state.
Donnelly, 45, was due to appear in court at a later date for bringing a gun to the airport, police said.
Copyright 2012 Thomson Reuters. Click for restrictions.
Source: http://www.msnbc.msn.com/id/45874890/ns/travel-news/
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WEDNESDAY Jan. 4, 2012 -- Some people with advanced colorectal cancer are resistant to some types of chemotherapy, and a mutation in the so-called TFAP2E gene may play a part in that resistance, German researchers report.
Knowing which patients carry the mutation might help doctors tailor treatments or develop new targets for therapy, the researchers said.
"In our study, we identified a gene which is frequently altered in colorectal cancer," said lead researcher Dr. Matthias P.A. Ebert, an assistant professor of internal medicine at the University of Magdeburg. "This genetic alteration is associated with increased resistance to chemotherapy and radiation in colorectal cancers."
The findings appear in the Jan. 5 issue of the New England Journal of Medicine.
For the study, Ebert's team analyzed how the TFAP2E gene functioned in colorectal cancer tumors.
Overall, they looked at more than 200 patients undergoing chemotherapy for advanced colorectal cancer. Among the first group of 74 patients, 38 had a mutation in this gene, the researchers found.
Mutated tumor cells in these and other patients made the cells resistant to fluorouracil, a widely used type of chemotherapy. However, the mutation did not make the tumor resistant to irinotecan or oxaliplatin, two other chemotherapy drugs, the researchers found.
In the rest of the patients after the first group, the researchers found a similar association between the TFAP2E gene mutation and tumors not responding to chemotherapy with fluorouracil.
"Chemotherapy and radiation is very helpful in the majority of patients with colon cancer and rectal cancers, respectively," Ebert said.
"If our studies are confirmed in prospective trials and by other groups, alteration of the TFAP2E gene could help identify subgroups of patients with colorectal cancer that would show good response to chemotherapy or radiation," he said.
Dr. Durado Brooks, director of the prostate and colorectal cancer division at the American Cancer Society, said "this is one more brick in the wall that is slowly helping us build our knowledge and understanding of how to attack cancer in new and different ways."
"If the findings are corroborated by other investigators, it could lead to testing of tumors to find if those tumors are likely to be resistant to fluorouracil-based chemotherapy," Brooks said.
It could also help identify new targets for treatment, he said.
Brooks thinks other gene mutations also affect how well chemotherapy works. Some genetic testing is done now for this purpose, he said; however, it's too soon to tell whether TFAP2E may be added to those tested, he said.
"This is a long way from moving into clinical practice," Brooks said.
"We need to know a lot more of how this impacts actual patients; all this data is based on looking at things under a microscope as opposed to investigating the impact of treatment in patients, which may turn out to be a little different," he said. "It's not ready to move from the lab bench to the bedside yet."
More information
To learn about colon cancer, visit the American Cancer Society.
Posted: January 2012
Source: http://www.drugs.com/news/gene-mutation-linked-chemo-resistant-colon-cancer-35712.html
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